You're at increased risk of serotonin syndrome if: Some people are more likely to be affected by the drugs and supplements that cause serotonin syndrome than are others, but the condition can occur in anyone. Ritonavir (Norvir), an anti-retroviral medication used to treat HIV.

Anti-nausea medications such as granisetron (Sancuso, Sustol), metoclopramide (Reglan), droperidol (Inapsine) and ondansetron (Zofran).Over-the-counter cough and cold medications containing dextromethorphan (Delsym).Illicit drugs, including LSD, ecstasy, cocaine and amphetamines.Pain medications, such as opioid pain medications including codeine, fentanyl (Duragesic, Abstral, others), hydrocodone (Hysingla ER), meperidine (Demerol), oxycodone (Oxycontin, Roxicodone, others) and tramadol (Ultram, ConZip).Anti-migraine medications, such as carbamazepine (Tegretol, Carbatrol, others), valproic acid and triptans, which include almotriptan, naratriptan (Amerge) and sumatriptan (Imitrex, Tosymra, others).Monoamine oxidase inhibitors (MAOIs), antidepressants such as isocarboxazid (Marplan) and phenelzine (Nardil).Tricyclic antidepressants, such as amitriptyline and nortriptyline (Pamelor).Bupropion (Zyban, Wellbutrin SR, Wellbutrin XL), an antidepressant and tobacco-addiction medication.Serotonin and norepinephrine reuptake inhibitors (SNRIs), antidepressants such as desvenlafaxine (Pristiq), levomilnacipran (Fetzima), milnacipran (Savella), duloxetine (Cymbalta, Drizalma Sprinkle) and venlafaxine (Effexor XR).Selective serotonin reuptake inhibitors (SSRIs), antidepressants such as citalopram (Celexa), fluoxetine (Prozac), fluvoxamine (Luvox), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle) and sertraline (Zoloft).The drugs and supplements that could potentially cause serotonin syndrome include: Illicit drugs and dietary supplements also may be associated with the condition. It may also occur if you take an antidepressant with an opioid pain medication.Īnother cause of serotonin syndrome is intentional overdose of antidepressant medications.Ī number of over-the-counter and prescription drugs may be associated with serotonin syndrome, especially antidepressants. Serotonin plays a role in regulating the digestive process, blood flow and breathing.Īlthough it's possible that taking just one drug that increases serotonin levels can cause serotonin syndrome in some people, this condition occurs most often when people combine certain medications.įor example, serotonin syndrome may occur if you take an antidepressant with a migraine medication. Other nerve cells in the body, primarily in the intestines, also produce serotonin. Typically, nerve cells in the brain and spinal cord produce serotonin that helps regulate attention, behavior and body temperature. This may not be a problem for newer plate readers that were created for these more complicated elisa kits that require a 4-parameter logistic curve fit to determine concentration.Request an Appointment at Mayo Clinic CausesĮxcessive accumulation of serotonin in the body creates the symptoms of serotonin syndrome. On a side note the kit contains total activity, nonspecific binding, and maximum binding wells which were hard for me to label on my older plate reader which had none of these options when I went to set up my plate in the plate reader protocol. On a positive note the directions were clear and easy to follow however you want to start this kit early in the day as there are two incubation steps that total three hours. One thing that surprised me about this kit is that it calls for 100uL of serum/sample and they want you to do the samples in duplicate which is an enormous amount of serum in my opinion. I would suggest anyone using this kit with rat serum samples should dilute the samples in half with the assay buffer. The kit gave decent results but I will say that the serotonin levels for my samples were significantly higher than the standard curve of the kit and also the standard error within treatment group was high. I used the serotonin elisa kit with rat serum samples of tbi, ptsd, and control treatment groups. Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder. Neurotoxic, Hepatotoxic and Nephrotoxic Effects of Tramadol Administration in Rats. Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin. Effects of GABA/ß-glucan supplements on melatonin and serotonin content extracted from natural resources. Alleviation of Anxiety/Depressive-Like Behaviors and Improvement of Cognitive Functions by Lactobacillus plantarum WLPL04 in Chronically Stressed Mice. Publishing research using ab133053? Please let us know so that we can cite the reference in this datasheet.Īb133053 has been referenced in 16 publications.

Exces de serotonina